Glad to see that our collaborative work with Rebeca Mejias, Tao Wong and others was published. This paper describes the effects of knocking out the Zdhhc15 gene in mice, mutations in which can cause Intellectual Disability in human patients. Congratulations to Rebeca, Tao and all other authors!
Plenty to report this month – first the publication of a paper by Kaitlin, focusing on retrograde signaling in Dorsal Root Ganglion neurons. You can read Kaitlin’s paper here, which was also selected as an Editors’ pick. Congratulations, Kaitlin!
Second, another publication by Shaun, with important contributions from Sely and Santi, which you can read here. This work was our first foray into regulation of the Axon Initial Segment by palmitoylation. Congratulations to all the Thomas lab members involved, and we also really appreciate the important contributions from our collaborators Tasso Tzingounis, Heun Soh and Randy Walikonis at UConn for this study.
And finally, this paper from Jingwen, Shaun and Heykyeong, which also featured important contributions from the labs of Yishi Jin, Michael Hayden, George Smith, and our former colleague here at Temple/Shriners, Yang Hu. This study reveals that a common enzyme, ZDHHC17, palmitoylates proteins that govern the survival of neuronal cell bodies and distal axons after nerve injury. This coupled control mechanism ensures that responses to axonal damage are appropriately coordinated in these two distinct locations.
Big congratulations to Shaun Sanders, who just accepted an offer to start her own lab at the University of Guelph. Shaun becomes the second Thomas lab postdoc to obtain their own independent faculty position – great job Shaun!
Gareth spoke at the International Society for Neurochemistry meeting in Montreal, in a session organized by Shernaz Bamji. Paul Jenkins and Elva Diaz were the other speakers in a very interesting session.
Luiselys (Sely) Hernandez, who worked in the lab during her very successful co-op placement in 2017-18, rejoined us as a Research Assistant. Welcome back, Sely!
Also this month, Gareth spoke at the FASEB conference on protein lipidation, this time in a new venue in upstate New York.
Congratulations to Shaun, whose work on roles of palmitoylation in mTOR signaling was just accepted for publication. You can read Shaun’s work here.
Our work on models of glaucoma was just selected for funding by the BrightFocus Foundation, a major philanthropic organization committed to advancing understanding of, and treatments for, neurodegeneration. We are very grateful to the BrightFocus donors for their support.
Congratulations, Dale, whose paper on high throughput screening to identify compounds that modulate DLK palmitoylation was just accepted for publication. You can read Dale’s work here. This study was a collaboration with groups at Temple University’s Moulder Center for Drug Discovery and Fox Chase Cancer Center’s High Throughput Screening Resource. As a nice coincidence the lab was also awarded a grant from NEI to follow up Dale’s work, in collaboration with Dr. Don Zack’s lab at the Wilmer Eye Institute at Johns Hopkins University Medical School.
A very good month for Shaun Sanders, who was awarded a Travel Bursary to attend the Biochemical Society meeting on S-acylation in Brighton in the United Kingdom. Shaun was not only then invited to give a short talk at the meeting, but won the prize for best Postdoctoral poster. Many congratulations, Shaun!
Heykyeong Jeong joins the lab as a senior postdoctoral Fellow after initial postdoctoral work in the lab of Dr. Shin Kang, also at Temple/Shriners. Welcome Heykyeong!
Many congratulations to Dale, who just accepted a faculty position in the Department of Biology at the University of Waterloo. Dale is the first Thomas lab member to start his own lab and we wish him every success!
Jingwen gave a great invited short talk on her work as part of the annual Society for Neuroscience meeting in Washington, DC. Well done, Jingwen!
Both Gareth and Dale spoke at the FASEB Conference on Protein Lipidation. There was good lab representation at this very enjoyable conference, which Shaun also attended.
Congratulations, Jingwen, who was an invited speaker at the Gordon Conference on ‘Neurotrophic Factors’ and by all accounts did a great job!
Congratulations Shaun, who was awarded a Postdoctoral Fellowship from the Brody Family Medical Trust. You can read the official announcement of Shaun’s award here. The lab went out to celebrate at Sate Kampar (Malaysian restaurant in South Philly – highly recommended!).
Congratulations to Sabrina whose review on axonal palmitoylation was just accepted for publication in the Journal of Neuroscience Research. You can read Sabrina’s review here. An image of Sabrina’s microfluidic neuronal cultures was also selected for the front cover of the journal.
Dale Martin joins the lab as a senior Postdoctoral Fellow following graduate studies with Luc Berthiamue and initial postodoctoral work with Michael Hayden. Welcome, Dale!
Congratulations, Sabrina, who was awarded the Poster Prize at Temple’s Translational Science Day for a second time! Great job, Sabrina!
The lab was awarded a Developmental Grant from Shriners Hospitals to use novel screening methods to identify a new class of neuroprotective compounds. This is our first foray into translational research and would not have been possible without great collaborators at Temple’s Moulder Center for Drug Discovery and the Fox Chase Cancer Center.
A busy month – Shaun Sanders joins the lab as a Postdoctoral Fellow following very successful graduate research with Michael Hayden, a world leader in the field of Huntington Disease.
Congratulations, Audrey, whose review on palmitoylation-dependent regulation or protein kinase signaling was just published. You can read her review here.
Jingwen Niu joins the lab after initial postdoctoral work at UPenn. Welcome, Jingwen!
Congratulations, Sabrina, whose work on DLK palmitoylation in nerve injury signaling was just accepted for publication in PNAS. You can read the final version of Sabrina’s paper here.
Francesca DeSimone joins the lab after very successful Ph.D. studies here at Temple University School of Medicine and at the University of Salerno, Italy. Welcome, Francesca!
Congratulations, Dr. Collura! Kaitlin gave a great seminar as part of her thesis defense, and the lab celebrated in style with her family. We’ll miss you, Kaitlin, but wish you the best of luck as you return to Medical School.
Congratulations, Joju, whose work on the regulation of dendritic spines by palmitoylated LIMK1 was just published in eLife.
Gareth, Sabrina and Kaitlin traveled to Cold Spring Harbor for the conference on “Axon Guidance, Synapse Formation and Regeneration”. Sabrina was an invited speaker and Kaitlin received a Travel Award from Temple Medical School to attend the meeting.
Congratulations, Kaitlin, who was awarded a Prize for her poster at Temple’s annual Dawn Marks Research Day.
Our collaborative work with Isabelle Maystadt on RSK2 and Coffin-Lowry Syndrome was just published.
Gareth’s review on palmitoylation-dependent regulation of glutamate receptors, co-written with Rick Huganir, was just published.
Congratulations to Sabrina, who was awarded the Postdoctoral Prize for her work at Temple’s First Annual Biomedical Research Day Symposium, and to Santi, who won first prize for his talk as part of Temple’s Summer Undergraduate Research Program.