Lab Members

Principal Investigator

Gareth M. Thomas, Ph.D

Gareth Thomas

Gareth is an Assistant Professor in the Shriners Hospitals Pediatric Research Center at Temple University School of Medicine, Philadelphia. He is also a member of Temple’s Anatomy and Cell Biology Department. Gareth obtained his undergraduate degree from the University of Cambridge and then did his graduate research in the laboratory of Sir Philip Cohen, a world leader in the field of protein kinase signaling. Gareth was then awarded a Wellcome Trust Fellowship to join the laboratory of Dr. Rick Huganir, Chair of the Department of Neuroscience at Johns Hopkins School of Medicine. In the Huganir Lab, Gareth developed an interest in the roles of the protein-lipid modification palmitoylation in the regulation of neuronal synapses. This work led to several key papers focusing on palmitoylation-dependent targeting of neurotransmitter receptors. Now, Gareth’s own laboratory combines the skills learned from the Cohen and Huganir Labs to focus on a largely unexplored area, namely how palmitoylation controls the localization and activity of neuronal protein kinases and other signaling enzymes. This work has broad implications for our understanding of how neuronal signaling is regulated in both health and disease.

Current Lab Members

Jingwen Niu, Postdoctoral Fellow.

jingwen-pic

I joined the lab after postdoctoral work with Drs. Wenqin Luo and Steve Thomas at UPenn. I am using mouse genetic approaches to determine novel roles for palmitoylation and am also carrying out studies of nerve injury responses in vivo.

Shaun Sanders, Postdoctoral Fellow.

I was a graduate student in the lab of Professor Michael Hayden at the University of British Columbia, where I studied a palmitoyl acyltrasferase that regulates Huntingtin, the gene product that is mutated in Huntington’s Disease. I joined the Thomas Lab in September 2016, where I am determining the roles of palmitoylation in retrograde trafficking and signaling.

Heykyeong Jeong, Postdoctoral Fellow

I carried out graduate school studies at Ajou University, South Korea on the response of astrocytes and microglia to nervous system injury. I carried out initial postdoctoral research in the laboratory of Dr. Shin Kang and joined the Thomas lab in August 2018. My research focuses on using genetically modified mice and Adeno-associated virus-mediated gene delivery to determine roles of palmitoylation in the nervous system in vivo.

Luiselys Hernandez, B.A.

Luiselys (Sely), a Drexel University graduate, carried out a very successful Co-op placement in the Thomas Lab in late 2017- early 2018. She re-joined the lab after her graduation in Summer 2019. Her work focuses on roles of palmitoylation in ion channel targeting and clustering.

Lab Alumni

Dale Martin, Postdoctoral Fellow.

Current position: Assistant Professor, University of Waterloo, ON, Canada

Francesca DeSimone, Postdoctoral Fellow.

fds-pic

Current position: Postdoctoral Fellow, Lab of Dr. Dianne Langford, Temple University School of Medicine

Sabrina Holland, Postdoctoral Fellow.

_CLC1236b

Current position: Associate Scientist, Lab of Dr. Gianluca Gallo, Temple University School of Medicine

Audrey Montersino, Postdoctoral Fellow.

IMGP5015

Current position: Development & Licensing Manager at Brain and Spine institute (ICM) & Institut de la Vision

Joju George, Postdoctoral Fellow.

Joju pic

Current position: Research Scientist, Elanco Animal Health in Indiana.

Kaitlin Collura, M.D./Ph.D. candidate

Kaitlin pic cropped

Current position: Pathology resident, Thomas Jefferson University

Santi Karnam, Temple Undergraduate Honors Student

IMAG0214-1

Current position: Ophthalmology Resident

Lauren Sibeck, Temple University Medical School Student

Current position: Resident, Family Medicine, University of Pittsburgh Medical Center St Margaret’s.

Prasad Kanuparthi, Temple University Medical School Student.

Current position: Clinical rotations, Temple University Medical School.