Publications

Selected publications:

Martin, DDO, Kanuparthi, P, Holland, SM, Sanders, SS, Jeong, HK, Einarson, MB, Jacobson, MA, Thomas, GM (2019). Identification of Novel Inhibitors of DLK Palmitoylation and Signaling by High Content ScreeningSci. Rep 9(1);3632.

Sanders, SS, De Simone, FI, Thomas GM (2019). mTORC1 signaling is palmitoylation-dependent in hippocampal neurons and non-neuronal cells and involves dynamic palmitoylation of LAMTOR1 and mTORFront. Cell. Neurosci. 13, 115.

Kridsada, K, Niu, J, Haldipur, P, Wang, Z, Ding, L, Li, JJ, Lindgren, AG, Herrera, E, Thomas GM, Chizhikov, VV, Millen, KJ, Luo, W (2018). Roof Plate-derived Radial Glial Cells Support Developmental Growth of Rapidly Adapting Mechanoreceptor Ascending AxonsCell Reports 23, 2928-2941.

Holland, SM and Thomas GM (2017). Roles of Palmitoylation in Axon Growth, Degeneration and Regeneration.  J. Neurosci. Res., 95, 1528-1539.

Holland, SM, Collura, KM, Ketschek, A, Noma, K, Ferguson, TA, Jin, Y, Gallo, G, Thomas, GM (2016). Palmitoylation controls DLK localization, interactions and activity to ensure effective axonal injury signalingProc Natl Acad Sci 113, 763-768.

Montersino, A, Thomas GM (2015). Slippery Signaling: Palmitoylation-dependent control of neuronal protein kinase localization and activity. Mol. Memb. Biol. 32, 179-188.

George, J, Soares, C, Montersino A, Beique JC, Thomas GM (2015). Palmitoylation of LIM Kinase-1 ensures spine-specific actin polymerization and morphological plasticity. eLife doi: 10.7554/eLife.06327.

Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljević N, Chaplin T, Xue L, Xu M, Foster JM, Karnam SS, James SY, Chioni AM, Gould D, Lorincz AT, Oliver RT, Chelala C, Thomas GM, Shipley JM, Mather SJ, Berney DM, Young BD, Lu YJ (2014). Identification of ZDHHC14 as a novel human tumour suppressor gene. J. Pathol. 232, 566-577.

Maystadt I, Destree A, Benoit V, Aeby A, Lederer D, Moortgat S, Jurkiewicz D, Krajewska-Walasek M, Hanauer A, Thomas GM (2014). RSK2 mutation co-segregates with X-linked intellectual disability and attenuated Coffin-Lowry phenotype in a three-generation family. Clinical Genetics 85, 96-99.

Thomas GM*, Hayashi, T* (2013). Smarter neuronal signaling complexes from existing components: How regulatory modifications were acquired during animal evolution. Bioessays. 35, 929-939. *co-corresponding authors

Thomas GM, Hayashi T, Huganir RL, Linden DJ (2013). DHHC8-dependent PICK1 palmitoylation is required for induction of cerebellar long-term synaptic depression. J. Neurosci, 33, 15401-15407.

Thomas, GM*, Huganir, RL* (2013). Palmitoylation of Glutamate receptors and their PDZ domain containing partners. Biochem Soc Trans 41, 72-78. *co-corresponding authors

Thomas GM, Hayashi T, Chiu SL, Chen CM, Huganir RL (2012). Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking. Neuron 73, 482-496.

Hayashi, T, Thomas, GM, Huganir, RL (2009). Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking. Neuron 64, 213-226.

Thomas, GM, Lin, DT, Nuriya, M, Huganir RL. (2008). Rapid and bi-directional regulation of AMPA Receptor phosphorylation and trafficking by JNK. EMBO Journal 27, 361-372.

Thomas, GM, Rumbaugh, G, Harrar, DB, Huganir, RL (2005). Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission. Proc Natl Acad Sci, 102, 15006-15011.

Thomas, GM, Huganir, RL (2004). MAPK cascade signaling and synaptic plasticity. Nat Rev. Neurosci. 5,173-183.